Sidelining Chemo

A study concludes that hormonal therapy is enough for many women with early-stage breast cancer

Most women with early-stage breast cancer do not need chemotherapy to beat it, a 10-year federally funded study has concluded. Conducted at 1,200 sites in the United States and five other countries, TAILORx reflects a diverse population of 10,273 women between the ages of 18 and 75.

โ€œThis is a practice-changing study. To know that chemo is not needed for 70 percent of women is just amazing,โ€ says Alejandra Perez, M.D., a study investigator and director of the University of Miami Sylvester Comprehensive Cancer Centerโ€™s Braman Family Breast Cancer Institute.

Perezโ€™s medical school professorโ€”Joseph A. Sparano, associate director for clinical research at the Albert Einstein School of Medicine and Montefiore Health System in New Yorkโ€”conceived the TAILORx study and was its lead author. He set out to answer questions perplexing the medical community for years: Is hormonal therapy sufficient to attack early-stage breast cancer, or do patients need a combination of hormones and chemo? Will hormone therapy alone keep breast cancer from returning post-surgery, prevent the development of a second, primary cancer, and, ultimately, save lives?

TAILORx (the Trial Assigning IndividuaLized Options for Treatment) enrolled women whose breast tumors had grown by receiving signals from estrogen and progesterone (hormone receptor-positive), were up to 5 centimeters in size (just under 2 inches), and had not spread to lymph nodes. The group also tested negative for an excess of the HER2 protein (human epidermal growth factor) found in aggressive cancers. Half of all breast cancers have these four characteristics.

Researchers then conducted a 21-gene test on each tumor removed during surgery to determine the risk of cancerโ€™s return after diagnosis and surgery. Women with a Breast Recurrence Score of 10 or less had very low risk if treated with hormone therapy alone, regardless of age, while women with a score of 26 or more had a high risk and would need hormone therapy and chemotherapy.

The right course of treatment for the 6,711 women with intermediate riskโ€”a score between 11 and 25โ€”was less clear. Calling this the โ€œgray zone,โ€ Perez says: โ€œThe patients were randomized. One group just had hormone therapy and another group also had chemo. It didnโ€™t make a difference. We learned that such women donโ€™t benefit from chemotherapy, and itโ€™s OK to treat them with hormone therapy alone.โ€

Indeed, after a nine-year period of cancer diagnosis, there is virtually no difference in survival rates for low- and intermediate-risk patients who received only hormone therapy (93.9 percent) and those who had it in combination with chemo (93.8 percent), according to the study presented June 3 at the 2018 American Society for Clinical Oncology Annual Meeting.

โ€œWe were waiting for the results to come in,โ€ says Louise Morrell, M.D., medical director of Boca Raton Regional Hospitalโ€™s Lynn Cancer Institute.

As part of National Cancer Survivors Day on June 4, the hospital held a Run for the Ribbons 5K, during which 1,000 participants raised funds for the institute. โ€œMy colleagues and I were cheering,โ€ Morrell says. โ€œWe were thrilled to have an answer.โ€

The results are even more meaningful to area women because the Boca Raton hospitalโ€™s patients participated in the study. The vast majority of patients with early-stage cancer can rest assured they donโ€™t need chemo, known to cause extreme nausea, fatigue, hair loss and weakened immune symptoms.

โ€œFor the last 10 or 15 years, weโ€™ve made decisions on these patients, but weโ€™ve had to be honest that we didnโ€™t know if chemo was needed or not,โ€ Morrell says. โ€œWe came to the best decision we could, without solid data behind it for anyone to be super comfortable.โ€

Now the hospitalโ€™s cancer teams, which include Morrell as geneticist, can provide accurate information.

โ€œFor a patient to say, โ€˜I need this treatmentโ€™ or โ€˜No, I donโ€™t need this,โ€™ itโ€™s like a gift.โ€

The Insider

News, notes and events connected to South Floridaโ€™s health, wellness and medical worlds

Reducing Cancer Scars: Whether breast cancer survivors choose reconstruction surgery or join the growing โ€œliving flatโ€ movement, one outcome remains the same: scars.

Lumpectomies and mastectomies can leave thick keloid scars filled with collagen bundles that typically burn or itch, says Khongruk Wongkittiroch, D.O., a board-certified general, cosmetic and surgical dermatologist.

But just as cancer treatments advance, so do technologies that reduce disfigurement. Wongkittiroch uses a multistep process to reduce the appearance of scars, beginning with a cortisone injection that thins the skin and relieves discomfort. Once Wongkittiroch flattens the skin, she uses a Fraxel carbon dioxide laser to slough off the scarโ€™s superficial layers and remold whatโ€™s underneathโ€”a process causing microzones of injury stimulating the bodyโ€™s repair mechanisms. She then draws blood to retrieve platelet-rich plasma (PRP).

โ€œWe take the PRP full of stem cells and growth factors and put it into the zone of injury, forcing the body to replace the scar with new collagen,โ€ she says, noting this is the same plasma that regenerates cartilage and hair growth.

Patients need three to five monthly treatments, which reduce the scarring by 40 percent to 70 percent. The remaining scar โ€œcan blend so itโ€™s not noticeable,โ€ she says.

Z-Roc, Wongkittirochโ€™s Fort Lauderdale dermatology practice, provides pro bono services on a case-by-case basis for women unable to pay. (954.564.0040, zrocderm.com)

Take the Leap for Cancer: Gildaโ€™s Club South Florida, which provides a supportive community for adults and children with cancer, is hosting its biggest fundraiser of the year on Oct. 6. If you like an adrenaline rush, then consider joining โ€œOver the Edgeโ€ at the AutoNation building in Fort Lauderdale, where participants will rappel from the 12th-floor garage. Hey, itโ€™s a unique way to view Las Olas.

The first 90 people to sign up (registration fee is $50) and raise at least $1,000 for the charity will be able to participate. โ€œWe hope to raise $100,000 this year,โ€ says Vanessa Seltzer, development director. (Visit gildasclubsouthflorida.org)

Kevin Gale
kgale@sfbwmag.com
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